According to a study conducted in 1958, the proportion of TBE in the total number of CNS viral diseases in Austria was 56%. Thus, before the start of the vaccination program, it was the most important and most frequent disease of this type in adults – with several hundred cases being reported each year.
In Switzerland, in 1981 TBE ranked fourth among viral infections of the central and peripheral nervous system, only picorna, mumps and Varicella zoster infections were more frequent. In some cantons, however, it was the most frequent cause of CNS diseases. In Germany, TBE accounts for up to 50% of all viral diseases, and in Lithuania TBE accounts for more than half (53%) of all CNS infections.

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