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TBE Meningococcal Disease Influenza Smallpox


Hospitalization is usually required for about three weeks; however, in severe cases it may last much longer, sometimes even several years. With rising age of the patient, especially in persons above 60, TBE increasingly takes a severe course, leading to paralysis and sometimes ending in death. The results of laboratory examinations seem to have little predictive value for the severity of the course of the disease, excluding CSF cell counts, which may indicate the intensity of CNS infection, and correlate with the severity of the disease. Similarily, TBE antibody concentration as detected by ELISA does not correlate with the outcome of the infection, whereas the neutralizing antibody titer together with the CNS cell count seems to be more predictive for the clinical outcome. At onset of disease, the presence of a low concentration of neutralizing antibodies in serum, and a high cell count in the CSF might indicate an unfavourable course of TBE.

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